CBP/p300 ligand 4
CBP/p300 ligand 4 (Compound 4) is an orally active inhibitor for CBP/p300 bromodomain, with IC50 of 91.4 nM. CBP/p300 ligand 4 serves as a ligand for target protein XYD190. XYD190 is a PROTAC degrader for CBP/p300[1].
Product Specifications
UNSPSC
12352005
Target
Epigenetic Reader Domain; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cbp-p300-ligand-4.html
Solubility
10 mM in DMSO
Smiles
O=C1CCC[C@H](N1C2=CC=C(C(F)=C2)F)C3=NC4=C(C=CC(C5=C(ON=C5C)C)=C4)N3C6CCN(CC(O)=O)CC6
Molecular Formula
C30H31F2N5O4
Molecular Weight
563.60
References & Citations
[1]Hu J, et al., Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong In Vivo Antitumor Activity. J Med Chem. 2024 May 9;67 (9) :6952-6986.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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