Almorexant
Almorexant (ACT 078573) is an orally active, potent and competitive dual orexin receptor antagonist, with Kd values of 1.3 nM (OX1) and 0.17 nM (OX2), respectively. Almorexant reversibly blocks signaling of orexin-A and orexin-B peptides. Almorexant totally blocked the intracellular Ca2+ signal pathway. Almorexant stimulates caspase-3 activity in AsPC-1 cells and induces apoptosis[1][2][3][4].
Product Specifications
CAS Number
871224-64-5
Product Name Alternative
ACT 078573
UNSPSC
12352005
Target
Apoptosis; Calcium Channel; Caspase; Orexin Receptor (OX Receptor)
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cancer; Endocrinology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/almorexant.html
Purity
99.96
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CNC([C@@H](C1=CC=CC=C1)N2CCC3=CC(OC)=C(OC)C=C3[C@@H]2CCC4=CC=C(C(F)(F)F)C=C4)=O
Molecular Formula
C29H31F3N2O3
Molecular Weight
512.56
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
Calcium Channel; Caspase 3; OX1 Receptor; OX2 Receptor
Citation 01
Available Sizes
Frequently Asked Questions
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