EUK-124

EUK 8 and EUK 134 are synthetic catalytic scavengers of reactive oxygen species with superoxide dismutase (SOD) and catalase mimetic activity.1 EUK 124 is a structural analog of EUK 8 and EUK 134 with significantly reduced activity. EUK 124 and EUK 8 inhibit superoxide-mediated reduction of an electron acceptor (i.e., SOD mimetic activity), with IC50 values of 5 μM and 0.7 μM, respectively.

Product Specifications

CAS Number

[186299-35-4]

UNSPSC

12352005

Target

SOD

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/euk-124.html

Smiles

[Cl-][Mn+3]123[N](CC[N]2=CC4=C(OC)C=C(OC)C=C4[O-]3)=CC5=C(C=C(OC)C=C5OC)[O-]1

Molecular Formula

C20H22ClMnN2O6

Molecular Weight

476.79

References & Citations

[1]Baker, et al. Synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: A key role for reactive oxygen species in ischemic brain injury. J. Pharmacol. Exp. Ther. 284 (1), 215-221 (1998) .