4-Phenylbutyric acid

[1]Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8 (4) :1206-12.|[2]Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29.|[3]Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. Biochem Pharmacol. 2018 May;151:9-17.

Acta Pharm Sin B. 2022 May;12 (5) :2315-2329.|Acta Pharm Sin B. 2024 Apr 23.|Adv Sci (Weinh) . 2024 Sep 19:e2403442.|Adv Sci (Weinh) . 2025 Jan 21:e2403992.|Anim Nutr. 2022 Oct 5:12:186-199.|Animals (Basel) . 2023 Jul 13;13 (14) :2291.|Antioxid Redox Signal. 2024 Jan;40 (1-3) :16-39.|Autophagy. 2021 Nov;17 (11) :3592-3606.|Behav Brain Res. 2024 Mar 28:462:114871.|BIO Web of Conferences. 2025 Mar 06.|Bioact Mater. 2023 Apr 14:27:257-270.|Biochem Biophys Rep. 2025 Jul 7:43:102143.|Biochem Biophys Rep. 2025 Sep 15:44:102262.|Biochem Biophys Res Commun. 2024 Oct 28:737:150916.|Biochem Pharmacol. 2022 Dec:206:115343.|Biochem Pharmacol. 2023 Aug:214:115666.|Biochem Pharmacol. 2023 Feb:208:115404.|Biochem Pharmacol. 2024 May:223:116194.|Biochem Pharmacol. 2025 Oct:240:117099.|Biochim Biophys Acta Mol Cell Biol Lipids. 2024 Aug 21:159559.|Biol Direct. 2025 Aug 22;20 (1) :94.|Biomedicines. 2024 Apr 18;12 (4) :902.|Biomedicines. 2025 Aug 6;13 (8) :1919.|Biomolecules. 2022 Nov 29;12 (12) :1778.|Biomolecules. 2024 Sep 8;14 (9) :1135.|bioRxiv. 2024 September 07.|BMC Complement Med Ther. 2022 May 5;22 (1) :125.|BMC Complement Med Ther. 2024 Nov 16;24 (1) :400.|BMC Oral Health. 2025 Sep 26;25 (1) :1472.|BMC Vet Res. 2025 Nov 17;21 (1) :673.|Br J Nutr. 2024 Feb 28;131 (4) :553-566.|Br J Pharmacol. 2022 Sep;179 (17) :4423-4439.|Bull Exp Biol Med. 2023 Mar;174 (5) :639-646.|Cancer Lett. 2021 Jul 1:509:13-25.|Cancer Lett. 2022 Feb 1:526:352-362.|Cell Biosci. 2025 Oct 31;15 (1) :150.|Cell Death Dis. 2020 Apr 24;11 (4) :279.|Cell Death Dis. 2021 Jun 11;12 (6) :606.|Cell Death Dis. 2022 Nov 10;13 (11) :951.|Cell Death Dis. 2024 Dec 18;15 (12) :890.|Cell Death Dis. 2024 Sep 30;15 (9) :702.|Cell Death Dis. 2025 Jul 11;16 (1) :512.|Cell Death Discov. 2023 Aug 14;9 (1) :296.|Cell Death Discov. 2024 Feb 20;10 (1) :91.|Cell Death Discov. 2024 Jun 8;10 (1) :275.|Cell Mol Biol Lett. 2023 Oct 12;28 (1) :79.|Cell Mol Neurobiol. 2025 May 29;45 (1) :53.|Cell Rep. 2025 Mar 26;44 (4) :115470.|Cell Signal. 2025 Jul:131:111753.|Cell Stress Chaperones. 2023 Jan;28 (1) :49-60.|Cell. 2025 Aug 7;188 (16) :4441-4455.e16.|Cells. 2022 Nov 26;11 (23) :3792.|Chem Biol Drug Des. 2024 Jan;103 (1) :e14433.|Chem Biol Interact. 2022 Oct 1:366:110125.|Chem Biol Interact. 2023 Sep 1:382:110592.|Chemosphere. 2022 Nov;307 (Pt 2) :135962.|Chemosphere. 2023 Jun:327:138463.|Commun Biol. 2024 Sep 5;7 (1) :1091.|Comput Biol Med. 2025 Oct 18;198 (Pt B) :111215.|Dev Cell. 2024 Jul 3:S1534-5807 (24) 00385-X.|Ecotoxicol Environ Saf. 2022 Oct 15:245:114099.|Ecotoxicol Environ Saf. 2023 Apr 15:255:114725.|Ecotoxicol Environ Saf. 2024 Aug 28:284:116946.|Ecotoxicol Environ Saf. 2024 Jul 3:281:116639.|Ecotoxicol Environ Saf. 2024 Nov 1:286:117243.|Ecotoxicol Environ Saf. 2025 Oct 15:305:119188.|Elife. 2020 Dec 7;9:e61405.|Endocr Connect. 2025 Aug 11;14 (8) :e250158.|Environ Int. 2023 Feb:172:107749.|Environ Int. 2023 Oct:180:108228.|Environ Pollut. 2024 Feb 15:343:123167.|Environ Toxicol. 2023 Aug;38 (8) :1874-1890.|Exp Neurol. 2024 May:375:114738.|Exp Ther Med. 2023 Sep 1;26 (4) :484.|FASEB J. 2025 Mar 31;39 (6) :e70345.|FASEB J. 2025 Nov 30;39 (22) :e71250.|FEBS Open Bio. 2025 Jul;15 (7) :1041-1053.|Fish Physiol Biochem. 2022 Feb;48 (1) :275-284.|Fish Shellfish Immunol. 2024 Nov 9:155:110020.|Food Chem Toxicol. 2020 Feb;136:111080.|Food Chem Toxicol. 2022 Aug:166:113263.|Food Chem Toxicol. 2023 Oct:180:114033.|Foods. 2023 Apr 11;12 (8) :1616.|Free Radic Biol Med. 2023 Sep:206:33-49.|Free Radic Biol Med. 2025 Aug 16:236:188-203.|Free Radic Biol Med. 2025 Jun:233:148-161.|Free Radic Biol Med. 2025 Nov 8:243:414-433.|Free Radic Biol Med. 2025 Sep 10:S0891-5849 (25) 00969-4.|Free Radic Biol Med. 2026 Jan:242:345-363.|Front Biosci (Landmark Ed) . 2024 Sep 24;29 (9) :334.|Front Cell Infect Microbiol. 2022 Jun 14:12:856711.|Front Oncol. 2021 Jul 7;11:663600.|Front Pharmacol. 2022 Mar 21;13:854506.|Immunol Res. 2025 Jun 27;73 (1) :100.|Int Immunopharmacol. 2022 Feb:103:107842.|Int Immunopharmacol. 2022 Feb:103:108489.|Int Immunopharmacol. 2025 Jan 4:147:113935.|Int Immunopharmacol. 2025 Jun 11:161:115005.|Int Immunopharmacol. 2025 Sep 13:165:115532.|Int J Biol Macromol. 2024 Jun 4;272 (Pt 2) :132870.|Int J Biol Macromol. 2024 Sep 11:135351.|Int J Biol Macromol. 2025 Dec;333 (Pt 2) :148770.|Int J Med Sci. 2024 Jan 1;21 (2) :341-356.|Int J Mol Med. 2025 May;55 (5) :77.|Int J Mol Sci. 2023 Feb 1;24 (3) :2749.|Int J Mol Sci. 2023 Jan 5;24 (2) :1015.|Int J Nanomedicine. 2025 Jan 30:20:1147-1169.|J Adv Res. 2025 Nov 7:S2090-1232 (25) 00877-X.|J Agric Food Chem. 2024 Feb 21;72 (7) :3741-3754.|J Agric Food Chem. 2025 Oct 29.|J Biochem Mol Toxicol. 2024 Nov;38 (11) :e70038.|J Burn Care Res. 2023 Sep 7;44 (5) :1231-1240.|J Carbohydr Chem. 2025 Jul 07.|J Dairy Sci. 2023 Jul;106 (7) :5146-5164.|J Ethnopharmacol. 2023 Mar 25:304:116028.|J Ethnopharmacol. 2023 Oct 5;319 (Pt 2) :117245.|J Ethnopharmacol. 2024 Apr 24:324:117759.|J Exp Clin Cancer Res. 2023 Jun 19;42 (1) :150.|J Funct Foods. 2020, 104178.|J Funct Foods. 2022, 99: 105336.|J Funct Foods. 2024 Apr, 115, 106102.|J Hazard Mater. 2023 Apr 15:448:130785.|J Lipid Res. 2024 Nov 4:100692.|J Neuroimmune Pharmacol. 2024 Jan 12;19 (1) :1.|J Orthop Surg Res. 2022 Nov 16;17 (1) :487.|J Transl Med. 2024 May 21;22 (1) :488.|Lab Invest. 2022 Nov;102 (11) :1192-1202.|Life Sci. 2023 Jun 1:322:121656.|Life Sci. 2025 Jul 19:379:123862.|Lipids Health Dis. 2025 Apr 12;24 (1) :138.|Lipids Health Dis. 2025 Feb 11;24 (1) :44.|Lipids Health Dis. 2025 Oct 7;24 (1) :312.|Mar Drugs. 2024 Apr 13, 22 (4), 174.|MedComm-Oncology. 2023 Feb 19.|Mol Biol Rep. 2023 Aug;50 (8) :6457-6468.|Mol Biol Rep. 2025 Aug 11;52 (1) :814.|Mol Carcinog. 2024 Sep;63 (9) :1783-1799.|Mol Immunol. 2021 Jul:135:294-303.|Mol Immunol. 2025 May:181:102-112.|Mol Med Rep. 2024 May;29 (5) :71.|Nat Cell Biol. 2024 Nov;26 (11) :1892-1902.|Nat Commun. 2025 Aug 29;16 (1) :8074.|Neurol Res. 2025 Nov 10:1-17.|Oncogene. 2024 Sep;43 (40) :2971-2985.|Oxid Med Cell Longev. 2021 Jun 16:2021:5552530.|Oxid Med Cell Longev. 2022 Apr 6;2022:1835900.|Oxid Med Cell Longev. 2022 May 5;2022:5695005.|PeerJ. 2022 May 12;10:e13376.|Pharmaceutical Science Advances. 2025 Dec.|Phytomedicine. 2025 Jul:142:156777.|Phytomedicine. 2025 Oct:146:157098.|Phytother Res. 2023 Jan;37 (1) :310-328.|Phytother Res. 2025 Jul 15.|Poult Sci. 2024 Jun;103 (6) :103656.|Res Sq. 2025 May 22.|Research Square Preprint. 2022 Jun.|Research Square Preprint. 2023 Jul 28.|Research Square Print. 2022 Aug.|Respir Res. 2023 Jun 2;24 (1) :149.|Respir Res. 2024 Nov 9;25 (1) :401.|Respir Res. 2025 Apr 12;26 (1) :136.|Sci Immunol. 2023 Sep 29;8 (87) :eabq2424.|Sci Rep. 2023 Jan 13;13 (1) :693.|Sci Rep. 2023 Jan 20;13 (1) :1147.|Sci Rep. 2023 Nov 9;13 (1) :19438.|Sci Rep. 2025 May 5;15 (1) :15659.|Sci Total Environ. 2023 Sep 20:892:164620.|Sci Total Environ. 2024 Jun 20:930:172582.|Sci Total Environ. 2024 Mar 10:915:170129.|Sci Total Environ. 2025 Apr 10:973:179048.|Small. 2023 Feb;19 (5) :e2204310.|SSRN. 2024 Jul 11.|SSRN. 2025 Apr 11.|SSRN. 2025 Mar 31.|SSRN. 2025 Nov 16.|Toxicol Lett. 2025 Jul 21:412:34-43.|Toxicology. 2022 May 15;473:153193.|Toxicology. 2024 Dec:509:153976.|Toxicology. 2024 Dec:509:153979.|Toxicology. 2024 Jul 18:153899.|Toxicology. 2024 May:504:153800.|Toxicon. 2025 Aug 7:266:108511.|Toxins. 2024 Oct 9;16 (10) :432.|Vet Microbiol. 2021 Feb:253:108959.|Vet Microbiol. 2023 Apr:279:109666.|Vet Microbiol. 2024 May:292:110051.|Vet Res. 2024 Jun 14;55 (1) :78.|Vet Res. 2025 Jul 15;56 (1) :150.|Virulence. 2025 Dec;16 (1) :2466482.|Viruses. 2023 Feb 14;15 (2) :534.|Am J Physiol Cell Physiol. 2025 Mar 1;328 (3) :C1076-C1089.|Arterioscler Thromb Vasc Biol. 2022 Mar;42 (3) :305-325.|Autophagy. 2022 Oct;18 (10) :2350-2367.|Biosci Rep. 2019 Aug 7;39 (8) :BSR20190578.|Cell Death Dis. 2018 Nov 16;9 (12) :1143. |Cell Stress Chaperones. 2022 May;27 (3) :273-283.|Chem Biol Interact. 2023 Jul 1:379:110523.|Ecotoxicol Environ Saf. 2022 May 1;236:113508.|FEBS Open Bio. 2020 Oct;10 (10) :2122-2136.|Food Chem Toxicol. 2020 Jun;140:111329.|Front Oncol. 2021 Oct 27;11:722624.|Front Pharmacol. 2021 May 24:12:685895.|Int Immunopharmacol. 2021 Dec;101 (Pt A) :108281.|Int Immunopharmacol. 2025 Aug 19:164:115386.|Int J Clin Exp Med. 2019;12 (5) :5184-5190.|J Invest Dermatol. 2025 Mar;145 (3) :631-644.e22.|J Mol Med (Berl) . 2019 Aug;97 (8) :1183-1193.|Lett Drug Des Discover. 2019 Nov.|Mol Neurobiol. 2025 May 26.|Nutr Metab. 2020 Jan 30;17:11.|Res Sq. 2024 Aug 21.|Toxicol Res (Camb) . 2021 Jan 5;10 (1) :18-28.|Vet Microbiol. 2025 Jun 3:307:110559.|Vet Res. 2023 Mar 22;54 (1) :27.