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4-Phenylbutyric acid

Product Specifications

UNSPSC Description

4-Phenylbutyric acid (4-PBA) is an inhibitor of HDAC and endoplasmic reticulum (ER) stress, used in cancer and infection research.

Target Antigen

HDAC; Virus Protease

Type

Reference compound

Related Pathways

Anti-infection;Cell Cycle/DNA Damage;Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/Benzenebutyric_acid.html

Purity

99.98

Solubility

DMSO : 100 mg/mL (ultrasonic)|H2O : 2 mg/mL (ultrasonic)

Smiles

O=C(O)CCCC1=CC=CC=C1

Molecular Weight

164.204

References & Citations

[1]Chang TH, et al. Enhanced growth inhibition by combination differentiation therapy with ligands of peroxisome proliferator-activated receptor-gamma and inhibitors of histone deacetylase in adenocarcinoma of the lung. Clin Cancer Res. 2002 Apr;8(4):1206-12.|[2]Frouco G, et, al. Sodium phenylbutyrate abrogates African swine fever virus replication by disrupting the virus-induced hypoacetylation status of histone H3K9/K14. Virus Res. 2017 Oct 15;242:24-29.|[3]Park HJ, et al. 4-Phenylbutyric acid protects against lipopolysaccharide-induced bone loss by modulating autophagy in osteoclasts. 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Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-A0281/4-Phenylbutyric-acid-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-A0281/4-Phenylbutyric-acid-SDS-MedChemExpress.pdf

Clinical Information

Launched

CAS Number

1821-12-1

Available Sizes

Curated Selection

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