RNF5 agonist 1

RNF5 agonist 1 (analog-1), a structural analog of RNF5 inhibitor inh-02 (HY-123967), is a potent RNF5 agonist. RNF5 agonist 1 increases the ubiquitylation status of ATG4B in F508del-CFTR-expressing CFBE41o- cells[1][2].

Product Specifications

CAS Number

[69909-92-8]

UNSPSC

12352005

Target

E1/E2/E3 Enzyme

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/rnf5-agonist-1.html

Smiles

CC1=NS/C(N1C2=CC=CC=C2)=N\C(C3=CC=CC=C3)=N\C4=CC=CC=C4

Molecular Formula

C22H18N4S

Molecular Weight

370.47

References & Citations

[1]Sondo E, et al. Pharmacological Inhibition of the Ubiquitin Ligase RNF5 Rescues F508del-CFTR in Cystic Fibrosis Airway Epithelia. Cell Chem Biol. 2018 Jul 19;25 (7) :891-905.e8. |[2]Li Z, et al. The E3 ligase RNF5 restricts SARS-CoV-2 replication by targeting its envelope protein for degradation. Signal Transduct Target Ther. 2023 Feb 3;8 (1) :53.