PhiKan 083

PhiKan 083 is a carbazole derivative, which binds to the surface cavity and stabilizes Y220C (a p53 mutant), with a Kd of 167 μM. PhiKan 083 can be used for cancer research[1].

Product Specifications

CAS Number

[880813-36-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PhiKan_083.html

Purity

98.93

Solubility

DMSO : 100 mg/mL (ultrasonic) |Ethanol : 100 mg/mL (ultrasonic)

Smiles

CNCC1=CC2=C(C=C1)N(CC)C3=C2C=CC=C3

Molecular Formula

C16H18N2

Molecular Weight

238.33

Precautions

H302, H315, H319, H335

References & Citations

[1]Boeckler FM, et al. Targeted rescue of a destabilized mutant of p53 by an in silico screened drug. Proc Natl Acad Sci U S A. 2008 Jul 29;105 (30) :10360-5.|[2]Rauf SM, et al. Effect of Y220C mutation on p53 and its rescue mechanism: a computer chemistry approach. Protein J. 2013 Jan;32 (1) :68-74.|[3]Paulmurugan R, et al. A protein folding molecular imaging biosensor monitors the effects of drugs that restore mutant p53 structure and its downstream function in glioblastoma cells. Oncotarget. 2018 Apr 20;9 (30) :21495-21511.