8-Deazahomofolic acid
8-Deazahomofolic acid is an inhibitor of thymidylate synthase (TS) and other folate-related enzymes. 8-Deazahomofolic acid shows inhibitory activity against folate-dependent S. faecium, L. casei, and MTX resistant strains. 8-Deazahomofolic acid also inhibits the growth of L1210 leukemia cells, with an IC50 value of 87.5 μM. 8-Deazahomofolic acid can be used in research on bacterial infections and tumors[1].
Product Specifications
CAS Number
111113-73-6
UNSPSC
12352005
Target
Bacterial; Thymidylate Synthase
Type
Reference compound
Related Pathways
Anti-infection; Apoptosis
Field of Research
Cancer; Infection
Assay Protocol
https://www.medchemexpress.com/8-deazahomofolic-acid.html
Smiles
O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(NCCC2=CC=C(C3=N2)NC(N)=NC3=O)C=C1)=O
Molecular Formula
C21H22N6O6
Molecular Weight
454.44
References & Citations
[1]DeGraw JI, et al. Synthesis and biological evaluation of 8-deazahomofolic acid and its tetrahydro derivative. J Med Chem. 1988 Jan;31 (1) :150-3.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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