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Chlamydocin (purity≥70%)

Chlamydocin (purity≥70%), a fungal metabolite, is a highly potent HDAC inhibitor, with an IC50 of 1.3 nM. Chlamydocin (purity≥70%) exhibits potent antiproliferative and anticancer activities. Chlamydocin (purity≥70%) induces apoptosis by activating caspase-3[1].

Product Specifications

CAS Number

53342-16-8

UNSPSC

12352209

Hazard Statement

H302+H312+H332-H315-H319-H335

Target

Apoptosis; HDAC

Type

Peptides

Related Pathways

Apoptosis; Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/chlamydocin.html

Solubility

10 mM in DMSO

Smiles

O=C1N2[C@@]([H])(C(N[C@@H](CCCCCC([C@@H]3CO3)=O)C(NC(C)(C(N[C@]1(CC4=CC=CC=C4)[H])=O)C)=O)=O)CCC2

Molecular Formula

C28H38N4O6

Molecular Weight

526.62

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]De Schepper S, et al. Inhibition of histone deacetylases by chlamydocin induces apoptosis and proteasome-mediated degradation of survivin. J Pharmacol Exp Ther. 2003;304 (2) :881-888.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Isoform

HDAC

Frequently Asked Questions

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