7-Nitroindazole (sodium)
Product Specifications
UNSPSC Description
7-Nitroindazole sodium is a selective and BBB-penatrable inhibitor of nitric oxide synthase (NOS). 7-Nitroindazole sodium can inhibit the activity of central NOS with an IC50 of 0.47 μM in the cerebellum of mice. 7-Nitroindazole sodium has anti-injurious and neuroprotective properties[1][2].
Target Antigen
NO Synthase
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/7-nitroindazole-sodium.html
Smiles
O=[N+](C1=CC=CC2=C1[N-]N=C2)[O-].[Na+]
Molecular Weight
185.12
References & Citations
[1]Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108(2):296-7.|[2]Moore PK, et al. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol. 1993 Sep;110(1):219-24.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-69019A/7-Nitroindazole-sodium-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-69019A/
Clinical Information
No Development Reported
CAS Number
161467-34-1
Curated Selection
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