7-Nitroindazole (sodium)

7-Nitroindazole sodium is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS) . 7-Nitroindazole sodium can inhibit the activity of central NOS with an IC50 of 0.47 μM in the cerebellum of mice. 7-Nitroindazole sodium has anti-injurious and neuroprotective properties[1][2].

Product Specifications

CAS Number

[161467-34-1]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

NO Synthase

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/7-nitroindazole-sodium.html

Smiles

O=[N+](C1=CC=CC2=C1[N-]N=C2)[O-].[Na+]

Molecular Formula

C7H4N3NaO2

Molecular Weight

185.12

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108 (2) :296-7.|[2]Moore PK, et al. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol. 1993 Sep;110 (1) :219-24.