L803-mts
L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM) . L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test[1][2].
Product Specifications
CAS Number
706785-93-5
Product Name Alternative
Myristoylated L 803; GSK-3β Inhibitor XIII
UNSPSC
12352209
Target
Amyloid-β; GSK-3
Type
Peptides
Related Pathways
Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/l803-mts.html
Purity
98.65
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C([C@H](CCC1)N1C([C@H](C)NC([C@H](CCC2)N2C([C@H](CCC3)N3C([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC(CNC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O)N(CCC4)[C@@H]4C(N[C@@H](CCC(N)=O)C(N[C@@H](CO[P](O)(O)=O)C(N(CCC5)[C@@H]5C(O)=O)=O)=O)=O
Molecular Formula
C66H109N14O21P
Molecular Weight
1465.63
References & Citations
[1]Kaidanovich-Beilin O, et al. Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol Psychiatry. 2004 Apr 15;55 (8) :781-4.|[2]Avrahami L, et al. Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies. J Biol Chem. 2013 Jan 11;288 (2) :1295-306.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
LY402627 100 µg
TRSPAP1 (TRNAU1AP) (NM_017846) Human Over-expression Lysate
Sign In for Pricing
View Details 