L803-mts

L803-mts (Myristoylated L 803) is a selective and substrate-competitive GSK-3 peptide inhibitor (IC50: 40 μM) . L803-mts also reduces Aβ deposits and ameliorates cognitive deficits in 5XFAD mice. L803-mts shows antidepressive effect in the forced swimming test[1][2].

Product Specifications

CAS Number

[706785-93-5]

Product Name Alternative

Myristoylated L 803; GSK-3β Inhibitor XIII

UNSPSC

12352209

Target

Amyloid-β; GSK-3

Type

Peptides

Related Pathways

Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/l803-mts.html

Purity

98.65

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=C([C@H](CCC1)N1C([C@H](C)NC([C@H](CCC2)N2C([C@H](CCC3)N3C([C@H](C)NC([C@H](CCC(O)=O)NC([C@H](CCCCN)NC(CNC(CCCCCCCCCCCCC)=O)=O)=O)=O)=O)=O)=O)=O)N(CCC4)[C@@H]4C(N[C@@H](CCC(N)=O)C(N[C@@H](CO[P](O)(O)=O)C(N(CCC5)[C@@H]5C(O)=O)=O)=O)=O

Molecular Formula

C66H109N14O21P

Molecular Weight

1465.63

References & Citations

[1]Kaidanovich-Beilin O, et al. Rapid antidepressive-like activity of specific glycogen synthase kinase-3 inhibitor and its effect on beta-catenin in mouse hippocampus. Biol Psychiatry. 2004 Apr 15;55 (8) :781-4.|[2]Avrahami L, et al. Inhibition of glycogen synthase kinase-3 ameliorates β-amyloid pathology and restores lysosomal acidification and mammalian target of rapamycin activity in the Alzheimer disease mouse model: in vivo and in vitro studies. J Biol Chem. 2013 Jan 11;288 (2) :1295-306.