Pan-KRAS-IN-6
Pan-KRAS-IN-6 (compound 12) is a potent pan KRAS inhibitor with IC50 values of 9.79 nM (Kras G12D) and 6.03 nM (Kras G12V) [1].
Product Specifications
CAS Number
3033565-36-2
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pan-kras-in-6.html
Solubility
10 mM in DMSO
Smiles
FC1=C(C2=C(N=C(N)S3)C3=C(F)C=C2)C(Cl)=CC4=C(N5CC(C)(O)COCC5)N=C(OC[C@@]6(CCC7)N7C[C@H](F)C6)N=C14
Molecular Formula
C29H30ClF3N6O3S
Molecular Weight
635.10
References & Citations
[1]홍창희, et al. Novel quinazoline compound as kras inhibitor.WO2024063576.2023-09-21
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras
Frequently Asked Questions
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