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Cercosporin

Cercosporin is produced by a plant pathogen, Pseudocercosporella capsellae. Cercosporin is a potent photosensitizer with a short activation wavelength, mostly suitable for superficial photodynamic therapy (PDT) treatments, especially when it is necessary to avoid perforations[1]. Cercosporin contains the perylenequinone structural features necessary to PKC activity with an IC50 of 0.6-1.3 μM[2].

Product Specifications

CAS Number

35082-49-6

Product Name Alternative

CGP049090

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

PKC

Type

Natural Products

Related Pathways

Epigenetics; TGF-beta/Smad

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cercosporin.html

Purity

98.90

Solubility

DMSO : ≥ 10 mg/mL

Smiles

O=C1C=C(C(C2=C34)=C5C1=C(O)C(OC)=C(C[C@H](O)C)C5=C4C(C[C@H](O)C)=C6OC)OCOC2=CC(O)=C3C6=O

Molecular Formula

C29H26O10

Molecular Weight

534.51

Precautions

H315, H319, H335

References & Citations

[1]Mastrangelopoulou M, et al. Cytotoxic and Photocytotoxic Effects of Cercosporin on Human Tumor Cell Lines. Photochem Photobiol. 2019 Jan;95 (1) :387-396.|[2]Morgan BJ, et al. Design, synthesis, and investigation of protein kinase C inhibitors: total syntheses of (+) -calphostin D, (+) -phleichrome, cercosporin, and new photoactive perylenequinones. J Am Chem Soc. 2009 Jul 8;131 (26) :9413-25.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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