Thalidomide-O-amido-C3-NH2 (TFA)

Thalidomide-O-amido-C3-NH2 TFA is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology.

Product Specifications

CAS Number

[2022182-58-5]

Product Name Alternative

Cereblon Ligand-Linker Conjugates 16 (TFA) ; E3 Ligase Ligand-Linker Conjugates 52 (TFA)

UNSPSC

12352005

Hazard Statement

H301, H312, H361

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugates-52-tfa.html

Purity

99.87

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(NCCCN)COC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O.OC(C(F)(F)F)=O

Molecular Formula

C20H21F3N4O8

Molecular Weight

502.40

Precautions

H301, H312, H361

References & Citations

[1]Lohbeck J, et al. Practical synthesis of a phthalimide-based Cereblon ligand to enable PROTAC development. Bioorg Med Chem Lett. 2016 Nov 1;26 (21) :5260-5262.