Isoandrographolide
Isoandrographolide possesses cell differentiation inducing and hepatoprotective effect. Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice[1][2].
Product Specifications
CAS Number
4176-96-9
UNSPSC
12352005
Target
NOD-like Receptor (NLR)
Type
Natural Products
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/isoandrographolide.html
Solubility
10 mM in DMSO
Smiles
C[C@]12[C@@]3([H])[C@](OC(C4=CCOC4=O)C3)(CC[C@]1([H])[C@@](C)([C@@H](CC2)O)CO)C
Molecular Formula
C20H30O5
Molecular Weight
350.45
References & Citations
[1]T Matsuda, et al. Cell differentiation-inducing diterpenes from Andrographis paniculata Nees. Chem Pharm Bull (Tokyo) . 1994 Jun;42 (6) :1216-25.|[2]Zhe Song, et al. Isoandrographolide inhibits NLRP3 inflammasome activation and attenuates silicosis in mice. Int Immunopharmacol. 2022 Apr;105:108539.
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
NLRP3
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