Nek2/Hec1-IN-2
Nek2/Hec1-IN-2 (Compound 14) is an inhibitor of Nek2/Hec1. Nek2/Hec1-IN-2 inhibits cancer cell proliferation with IC50 >25 μM[1].
Product Specifications
CAS Number
[544416-00-4]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
NEKs
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nek2-hec1-in-2.html
Purity
98.0
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(C1=NC=CN=C1)NC2=NC(C3=C(C)C=C(C)C=C3)=CS2
Molecular Formula
C16H14N4OS
Molecular Weight
310.37
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Qiu XL, et al. Synthesis and biological evaluation of a series of novel inhibitor of Nek2/Hec1 analogues. J Med Chem. 2009 Mar 26;52 (6) :1757-67.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
NEK2
Available Sizes
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