Anti-FK-506 Antibody
Mouse Monoclonal Antibody specific to FK-506
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Anti-FK-506 Mouse Monoclonal Antibody
Host
Mouse
Reactivity
Fk-506
Immunogen
FK-506 conjugated to bovine serum albumin.
Target
FK-506
Clonality
Monoclonal
Isotype
IgM
Type
Antibody
Applications
ELISA, WB
Field of Research
Drugs
Purification Method
Purified by immunoaffinity chromatography
Concentration
Lot Specific
Dilution
Dilute in PBS or medium that is identical to that used in the assay system.
Format
Purified
Form
Liquid
Buffer
Phosphate Buffered Saline
Additionnal Information
This antibody may be used in ELISA and Western blotting to detect FK-506.
Storage Conditions
This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles.
Specificity
This antibody recognizes conjugated and non-conjugated FK-506 (Kd=10-9 M).
Formulation
PBS containing 0.1% sodium azide
Target Background
FK-506 is a novel macrolide with similar, but more potent, immunosuppressant activity than cyclosporine. FK-506 is used for primary or rescue immunosuppression in patients after solid organ transplantation. Clinically relevant side effects of FK-506 administration are nephrotoxicity, neurotoxicity, diabetes mellitus, and hypertension. Most of these side effects are related to blood levels of FK-506 rather than dosage. Therefore, therapeutic drug monitoring of FK-506 is a prerequisite for therapy. The whole blood target level range aimed for in clinical practice is 3.0-20.0 ng/ml and depends on the patient's liver function, the nature of organ transplantation, and the time after transplantation.
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