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Phenserine (tartrate)

Phenserine tartrate ((-) -Eseroline phenylcarbamate) is a derivative of Physostigmine and is a potent, noncompetitive, long-acting and selective AChE inhibitor. Phenserine tartrate reduces β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ) formation. Phenserine tartrate improves cognitive performance and attenuates the progression of Alzheimer's disease[1][2][3].

Product Specifications

CAS Number

156910-61-1

Product Name Alternative

(-) -Eseroline phenylcarbamate (tartrate) ; (-) -Phenserine (+) -tartrate

UNSPSC

12352005

Target

Amyloid-β; Cholinesterase (ChE)

Type

Reference compound

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/phenserine-tartrate.html

Smiles

OC([C@H](O)[C@@H](O)C(O)=O)=O.C[C@]12C3=CC(OC(NC4=CC=CC=C4)=O)=CC=C3N([C@@]1([H])N(CC2)C)C

Molecular Formula

C24H29N3O8

Molecular Weight

487.50

References & Citations

[1]Klein J. Phenserine. Expert Opin Investig Drugs. 2007 Jul;16 (7) :1087-97.|[2]Asuni AA, et al. Modulation of amyloid precursor protein expression reduces β-amyloid deposition in a mouse model. Ann Neurol. 2014 May;75 (5) :684-99.|[3]https://www.ncbi.nlm.nih.gov/pubmed/24687915

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

Phase 1

Frequently Asked Questions

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