GS-6620
GS-6620 is potent and selective HCV inhibitor. GS-6620 inhibits HCV replication in genotype 1-6 subgenomic replicons and genotype 2a infectious virus, with EC50 values of 0.048-0.68 μM. GS-6620 can be used for the researches of infection and inflammation, such as Hepatitis C Virus (HCV) [1][2].
Product Specifications
CAS Number
1350735-70-4
UNSPSC
12352005
Target
HCV
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/gs-6620.html
Purity
98.93
Solubility
10 mM in DMSO
Smiles
NC1=NC=NN2C1=CC=C2[C@@]3(C#N)[C@@](O)(C)[C@H](OC(C(C)C)=O)[C@@H](CO[P@](OC4=CC=CC=C4)(N[C@@H](C)C(OC(C)C)=O)=O)O3
Molecular Formula
C29H37N6O9P
Molecular Weight
644.61
References & Citations
[1]Joy Y Feng, et al. Inhibition of hepatitis C virus replication by GS-6620, a potent C-nucleoside monophosphate prodrug. Antimicrob Agents Chemother. 2014;58 (4) :1930-42.|[2]Cho A, et al. Discovery of the first C-nucleoside HCV polymerase inhibitor (GS-6620) with demonstrated antiviral response in HCV infected patients. J Med Chem. 2014 Mar 13;57 (5) :1812-25.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
Frequently Asked Questions
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