KLH45

KLH45 is a potent and selective DDHD2 inhibitor, with an IC50 of 1.3 nM[1].

Product Specifications

CAS Number

[1632236-44-2]

UNSPSC

12352005

Hazard Statement

H225, H319

Target

Phosphatase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/klh45.html

Concentration

10mM

Purity

99.81

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(N1N=CC(C2=CC=C(OC(F)(F)F)C=C2)=N1)N(C3CCCCC3)CCC4=CC=CC=C4

Molecular Formula

C24H25F3N4O2

Molecular Weight

458.48

Precautions

H225, H319

References & Citations

[1]Jordon M Inloes, et al. The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc Natl Acad Sci U S A. 2014 Oct 14;111 (41) :14924-9.|[2]Jordon M Inloes, et al. Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry. 2018 Feb 6;57 (5) :827-838.