KLH45
KLH45 is a potent and selective DDHD2 inhibitor, with an IC50 of 1.3 nM[1].
Product Specifications
CAS Number
1632236-44-2
UNSPSC
12352005
Hazard Statement
H225, H319
Target
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/klh45.html
Concentration
10mM
Purity
99.81
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1N=CC(C2=CC=C(OC(F)(F)F)C=C2)=N1)N(C3CCCCC3)CCC4=CC=CC=C4
Molecular Formula
C24H25F3N4O2
Molecular Weight
458.48
Precautions
H225, H319
References & Citations
[1]Jordon M Inloes, et al. The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase. Proc Natl Acad Sci U S A. 2014 Oct 14;111 (41) :14924-9.|[2]Jordon M Inloes, et al. Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets. Biochemistry. 2018 Feb 6;57 (5) :827-838.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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