HBC
HBC (HBC 530) is a GFP fluorophore-like synthetic dye, with a structurally rigid electron acceptor and a strong electron donor. HBC is nonfluorescent in solution, and when combined with Pepper (RNA aptamer), HBC forms a tight complex and activates and emits bright fluorescence (Kd of ~3.5 nM) . HBC emission peaks vary in different complexes and covers the spectrum from cyan to red. HBC can be used in the live cell imaging of RNA (Em/Ex = 530/485 nm) [1].
Product Specifications
CAS Number
[156840-13-0]
Product Name Alternative
HBC 530
UNSPSC
12171500
Hazard Statement
H301, H319
Target
Fluorescent Dye
Type
Dye Reagents
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/hbc.html
Purity
99.69
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(/C(C#N)=C\C2=CC=C(N(CCO)C)C=C2)C=C1
Molecular Formula
C19H17N3O
Molecular Weight
303.36
Precautions
H301, H319
References & Citations
[1]Chen X, et al. Visualizing RNA dynamics in live cells with bright and stable fluorescent RNAs. Nat Biotechnol. 2019;37 (11) :1287-1293.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Dye Reagents
Clinical Information
Phase 2
Available Sizes
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