NRC-2694
NRC-2694 is an epidermal growth factor receptor (EGFR) antagonist with anti-cancer and anti-proliferative properties. NRC-2694 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
[936446-61-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling; Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/NRC-2694.html
Purity
99.84
Solubility
DMSO : 250 mg/mL (ultrasonic)
Smiles
COC1=CC2=NC=NC(NC3=CC=CC(C#C)=C3)=C2C=C1OCCCN4CCOCC4
Molecular Formula
C24H26N4O3
Molecular Weight
418.49
Precautions
H302, H315, H319, H335
References & Citations
[1]Ramanadham Jyothi Prasad, et al. 6-7, dialkoxy quinazoline derivatives useful for treatment of cancer related disorders. US 8143250 B2
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
EGFR/ErbB1/HER1
Available Sizes
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