GSK-3 inhibitor 3

GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimer’s disease model, with IC50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research[1].

Product Specifications

CAS Number

[2227279-84-5]

UNSPSC

12352005

Target

CDK; GSK-3; Tau Protein

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/gsk-3-inhibitor-3.html

Purity

98.72

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

FC1=CC=C(C2=C(C=NC=C2)NC(C3=CC=NC(NC4=CC=C(C#N)C=C4)=N3)=O)C=C1

Molecular Formula

C23H15FN6O

Molecular Weight

410.40

References & Citations

[1]Hartz RA, et.al. Discovery of 2- (Anilino) pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors. J Med Chem. 2023 Jun 8;66 (11) :7534-7552.