GSK-3 inhibitor 3
Product Specifications
UNSPSC Description
GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimer’s disease model, with IC50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research[1].
Target Antigen
CDK; GSK-3; Tau Protein
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Neuronal Signaling;PI3K/Akt/mTOR;Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gsk-3-inhibitor-3.html
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C2=C(C=NC=C2)NC(C3=CC=NC(NC4=CC=C(C#N)C=C4)=N3)=O)C=C1
Molecular Weight
410.40
References & Citations
[1]Hartz RA, et.al. Discovery of 2-(Anilino)pyrimidine-4-carboxamides as Highly Potent, Selective, and Orally Active Glycogen Synthase Kinase-3 (GSK-3) Inhibitors. J Med Chem. 2023 Jun 8;66(11):7534-7552.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-154851/GSK-3-inhibitor-3-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-154851/GSK-3-inhibitor-3-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2227279-84-5
Available Sizes
Curated Selection
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