GSK-3 inhibitor 3
GSK-3 inhibitor 3 is a selective, orally active and brain-penetrant inhibitor of GSK-3, with IC50s of 0.35 nM and 0.25 nM for GSK-3α and GSK-3β, respectively. GSK-3 inhibitor 3 lowers levels of tau protein phosphorylation at S396 in a triple-transgenic mouse Alzheimer’s disease model, with IC50 of 10 nM. GSK-3 inhibitor 3 can be used for neurological disease research[1].
Product Specifications
CAS Number
[2227279-84-5]
UNSPSC
12352005
Target
CDK; GSK-3; Tau Protein
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gsk-3-inhibitor-3.html
Purity
98.72
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
FC1=CC=C(C2=C(C=NC=C2)NC(C3=CC=NC(NC4=CC=C(C#N)C=C4)=N3)=O)C=C1
Molecular Formula
C23H15FN6O
Molecular Weight
410.40
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK2; CDK5; GSK-3α; GSK-3β
Available Sizes
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