Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

SGC-SMARCA-BRDVIII

SGC-SMARCA-BRDVIII, a chemical probe, is a potent and selective inhibitor of SMARCA2/4 and PB1 (5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1 (2) and PB1 (3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts[1][2].

Product Specifications

CAS Number

1997319-84-2

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sgc-smarca-brdviii.html

Concentration

10mM

Purity

99.66

Solubility

DMSO : 23.33 mg/mL (ultrasonic)

Smiles

O=C(N1CCN(CC1)C2=C(N)N=NC(C3=CC=CC=C3O)=C2)OC(C)(C)C

Molecular Formula

C19H25N5O3

Molecular Weight

371.43

References & Citations

[1]Wanior M, et, al. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J Med Chem. 2020 Dec 10;63 (23) :14680-14699.|[2]Mélin L, et, al. Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2. ACS Omega. 2021 Aug 9;6 (33) :21327-21338.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

IL17 (IL17A) Mouse Monoclonal Antibody [Clone ID: OTI7E6]
CF814595 100 µg

IL17 (IL17A) Mouse Monoclonal Antibody [Clone ID: OTI7E6]

Sign In for Pricing
View Details
BOB1 (POU2AF1) Mouse Monoclonal Antibody [Clone ID: OTI3A5]
CF807990 100 µg

BOB1 (POU2AF1) Mouse Monoclonal Antibody [Clone ID: OTI3A5]

Sign In for Pricing
View Details
Cardboard Freezer Boxes
R2781 5 Units/Pack

Cardboard Freezer Boxes

Sign In for Pricing
View Details
CD81 Recombinant Monoclonal Mouse Antibody (2304.81), CF®583R Conjugate - Biotium Choice
P014-583R-500 1x 500 µL

CD81 Recombinant Monoclonal Mouse Antibody (2304.81), CF®583R Conjugate - Biotium Choice

Sign In for Pricing
View Details
Additional platform separators (4 ea.) . Adds 1.25" to platform separation
BR2000-SP 1 Each

Additional platform separators (4 ea.) . Adds 1.25" to platform separation

Sign In for Pricing
View Details
CDV3 (NM_001134422) Human Over-expression Lysate
LC427429 20 µg

CDV3 (NM_001134422) Human Over-expression Lysate

Sign In for Pricing
View Details