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SGC-SMARCA-BRDVIII

SGC-SMARCA-BRDVIII, a chemical probe, is a potent and selective inhibitor of SMARCA2/4 and PB1 (5), with Kds of 35 nM, 36 nM, and 13 nM, respectively. SGC-SMARCA-BRDVIII also inhibits PB1 (2) and PB1 (3), with Kds of 3.7 and 2.0 μM, respectively. SGC-SMARCA-BRDVIII can block adipogenesis of 3T3-L1 murine fibroblasts[1][2].

Product Specifications

CAS Number

1997319-84-2

UNSPSC

12352005

Target

Epigenetic Reader Domain

Type

Reference compound

Related Pathways

Epigenetics

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/sgc-smarca-brdviii.html

Concentration

10mM

Purity

99.66

Solubility

DMSO : 23.33 mg/mL (ultrasonic)

Smiles

O=C(N1CCN(CC1)C2=C(N)N=NC(C3=CC=CC=C3O)=C2)OC(C)(C)C

Molecular Formula

C19H25N5O3

Molecular Weight

371.43

References & Citations

[1]Wanior M, et, al. Pan-SMARCA/PB1 Bromodomain Inhibitors and Their Role in Regulating Adipogenesis. J Med Chem. 2020 Dec 10;63 (23) :14680-14699.|[2]Mélin L, et, al. Design and Synthesis of LM146, a Potent Inhibitor of PB1 with an Improved Selectivity Profile over SMARCA2. ACS Omega. 2021 Aug 9;6 (33) :21327-21338.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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