Narchinol B

Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α) . Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC50=2.43 μM) [1].

Product Specifications

CAS Number

[1356822-09-7]

UNSPSC

12352211

Target

Others

Type

Natural Products

Related Pathways

Others

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/narchinol-b.html

Solubility

10 mM in DMSO

Smiles

C[C@@]([C@@H](C1)C)([C@@H](C=C2)O)C(C2=O)=C[C@H]1O

Molecular Formula

C12H16O3

Molecular Weight

208.25

References & Citations

[1]Yoon CS, et al. Anti-neuroinflammatory effects of sesquiterpenoids isolated from Nardostachys jatamansi. Bioorg Med Chem Lett. 2018 Jan 15;28 (2) :140-144.