Narchinol B
Narchinol B (Compound 4) is a sesquiter penoid compound. Narchinol B has anti-inflammatory effects. Narchinol B works by inhibiting proinflammatory mediators, including prostaglandin E2 (PGE2), inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX-2) proteins, as well as proinflammatory cytokines, such as interleukin-1b, IL-6, and tumor necrosis factor-α (TNF-α) . Narchinol B significantly inhibits LPS-induced overproduction of NO in BV2 cells (IC50=2.43 μM) [1].
Product Specifications
CAS Number
[1356822-09-7]
UNSPSC
12352211
Target
Others
Type
Natural Products
Related Pathways
Others
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/narchinol-b.html
Solubility
10 mM in DMSO
Smiles
C[C@@]([C@@H](C1)C)([C@@H](C=C2)O)C(C2=O)=C[C@H]1O
Molecular Formula
C12H16O3
Molecular Weight
208.25
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Natural Products
Clinical Information
No Development Reported
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