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COX-2/LOX-IN-1

COX-2/LOX-IN-1 (compound 5) is a dual cyclooxygenase-2/lipoxygenase (COX-2/LOX) inhibitor with IC50s of 30 μM and 0.55 μM, for LOX and COX-2, respectively. [1].

Product Specifications

UNSPSC

12352005

Target

COX; Lipoxygenase

Type

Reference compound

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/cox-2-lox-in-1.html

Solubility

10 mM in DMSO

Smiles

CN(C)C(C=C1)=CC=C1/C=C/C2=CN(C=C2C(C3=CC=CC=C3)=O)C(/C=C/C4=CC=CC=C4)=O

Molecular Formula

C30H26N2O2

Molecular Weight

446.54

References & Citations

[1]Noti V, et al., Development of Novel Pyrrole Derivatives and Their Cinnamic Hybrids as Dual COX-2/LOX Inhibitors. Molecules. 2023 Dec 5;28 (24) :7958.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

COX-2

Curated Selection

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