COX-2/LOX-IN-1
COX-2/LOX-IN-1 (compound 5) is a dual cyclooxygenase-2/lipoxygenase (COX-2/LOX) inhibitor with IC50s of 30 μM and 0.55 μM, for LOX and COX-2, respectively. [1].
Product Specifications
UNSPSC
12352005
Target
COX; Lipoxygenase
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/cox-2-lox-in-1.html
Solubility
10 mM in DMSO
Smiles
CN(C)C(C=C1)=CC=C1/C=C/C2=CN(C=C2C(C3=CC=CC=C3)=O)C(/C=C/C4=CC=CC=C4)=O
Molecular Formula
C30H26N2O2
Molecular Weight
446.54
References & Citations
[1]Noti V, et al., Development of Novel Pyrrole Derivatives and Their Cinnamic Hybrids as Dual COX-2/LOX Inhibitors. Molecules. 2023 Dec 5;28 (24) :7958.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
COX-2
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