Tofogliflozin (hydrate)

Tofogliflozin hydrate (CSG-452 hydrate) is a potent and highly specific sodium/glucose cotransporter 2 (SGLT2) inhibitor with an IC50 of 2.9 nM and Ki values of 2.9 nM, 14.9 nM, and 6.4 nM for human, rat, and mouse SGLT2[1]. Tofogliflozin partially inhibits high glucose-induced reactive oxyen species (ROS) generation in tubular cells[2].

Product Specifications

CAS Number

[1201913-82-7]

Product Name Alternative

CSG-452 hydrate

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Reactive Oxygen Species (ROS) ; SGLT

Type

Reference compound

Related Pathways

Immunology/Inflammation; Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; NF-κB

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Tofogliflozin-hydrate.html

Concentration

10mM

Purity

98.38

Solubility

DMSO : ≥ 100 mg/mL|H2O : 0.33 mg/mL (ultrasonic)

Smiles

O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@]21OCC3=C2C=C(CC4=CC=C(CC)C=C4)C=C3.O

Molecular Formula

C22H28O7

Molecular Weight

404.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Suzuki M, et al. Tofogliflozin, a potent and highly specific sodium/glucose cotransporter 2 inhibitor, improves glycemic control in diabetic rats and mice. J Pharmacol Exp Ther. 2012 Jun;341 (3) :692-701.|[2]Ishibashi Y, et al. Tofogliflozin, A Highly Selective Inhibitor of SGLT2 Blocks Proinflammatory and Proapoptotic Effects of Glucose Overload on Proximal Tubular Cells Partly by Suppressing Oxidative Stress Generation. Horm Metab Res. 2016 Mar;48 (3) :191-5.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Launched

Isoform

SGLT2

Citation 01

Biochem Pharmacol. 2018 Jun:152:45-59.|University of Paris. 2022 Sep 19.|Biochem Pharmacol. 2016 Feb 1:101:27-39.|J Chromatogr B Analyt Technol Biomed Life Sci. 2020 Mar 15;1141:122020.