5-O-Demethylnobiletin

5-O-Demethylnobiletin (5-Demethylnobiletin), a polymethoxyflavone isolated from Citrus jambhiri Lush., is a direct inhibition of 5-LOX (IC50=0.1 μM), without affecting the expression of COX-2. 5-O-Demethylnobiletin (5-Demethylnobiletin) has anti-inflammatory activity, inhibits leukotriene B (4) (LTB4) formation in rat neutrophils and elastase release in human neutrophils with an IC50 of 0.35 μM[1].

Product Specifications

CAS Number

[2174-59-6]

Product Name Alternative

5-Demethylnobiletin

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Leukotriene Receptor; Lipoxygenase

Type

Natural Products

Related Pathways

GPCR/G Protein; Metabolic Enzyme/Protease

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/5-o-demethylnobiletin.html

Purity

99.91

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=C(OC)C(OC)=C(OC)C(O)=C13

Molecular Formula

C20H20O8

Molecular Weight

388.37

Precautions

H315, H319, H335

References & Citations

[1]Bas E, et al. Anti-inflammatory activity of 5-O-demethylnobiletin, a polymethoxyflavone isolated from Sideritis tragoriganum. Planta Med. 2006 Feb;72 (2) :136-42.|[2]Chiu SP, et al. Neurotrophic action of 5-hydroxylated polymethoxyflavones: 5-demethylnobiletin and gardenin A stimulate neuritogenesis in PC12 cells. J Agric Food Chem. 2013 Oct 2;61 (39) :9453-63.