5-HT/NA Reuptake inhibitor-1

5-HT/NA Reuptake inhibitor-1 (compound 9) is a selective dual 5-HT and NA reuptake inhibitor with IC50 of 660 nM and 70 nM respectively. . 5-HT/NA Reuptake inhibitor-1 has good in vitro human metabolic stability, hERG selectivity and passive membrane permeability[1].

Product Specifications

CAS Number

[844882-78-6]

UNSPSC

12352005

Target

5-HT Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/5-ht-na-reuptake-inhibitor-1.html

Solubility

10 mM in DMSO

Smiles

CN(C)CC1=C(C=CC=C1)OC2=CC=CC=C2

Molecular Formula

C15H17NO

Molecular Weight

227.30

References & Citations

[1]Whitlock GA, et al. 1- (2-Phenoxyphenyl) methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity. Bioorg Med Chem Lett. 2008 Jan 15;18 (2) :596-9.