5-HT/NA Reuptake inhibitor-1
5-HT/NA Reuptake inhibitor-1 (compound 9) is a selective dual 5-HT and NA reuptake inhibitor with IC50 of 660 nM and 70 nM respectively. . 5-HT/NA Reuptake inhibitor-1 has good in vitro human metabolic stability, hERG selectivity and passive membrane permeability[1].
Product Specifications
CAS Number
[844882-78-6]
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/5-ht-na-reuptake-inhibitor-1.html
Solubility
10 mM in DMSO
Smiles
CN(C)CC1=C(C=CC=C1)OC2=CC=CC=C2
Molecular Formula
C15H17NO
Molecular Weight
227.30
References & Citations
[1]Whitlock GA, et al. 1- (2-Phenoxyphenyl) methanamines: SAR for dual serotonin/noradrenaline reuptake inhibition, metabolic stability and hERG affinity. Bioorg Med Chem Lett. 2008 Jan 15;18 (2) :596-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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