Proteinase 3 (PR3, Highly Pure)

<strong>Proteinase 3 (PR3, Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2010443_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 29 kDa_x000D_ <strong>Supplied as:</strong> Buffered aqueous solution_x000D_ <strong>Appearance:</strong> Solution_x000D_ <strong>Applications:</strong> highly pure serine protease expressed in the granules of neutrophils and monocytes._x000D_ <strong>Storage:</strong> ‚àí20¬∞C_x000D_ <strong>Keywords:</strong> Myeloblastin, PR3 Ag, PR-3, P29B, AGP7_x000D_ <strong>Grade:</strong> Biotechnology grade. All solid components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MŒ©-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Grzywa R, Lesner A, Korkmaz B, Sie≈Ñczyk M. Proteinase 3 phosphonic_x000D_ inhibitors. Biochimie. 2019 Nov;166:142-149._x000D_ _x000D_ 2: Korkmaz B, Horwitz MS, Jenne DE, Gauthier F. Neutrophil elastase, proteinase_x000D_ 3, and cathepsin G as therapeutic targets in human diseases. Pharmacol Rev. 2010_x000D_ Dec;62(4):726-59._x000D_ _x000D_ 3: Martin KR, Witko-Sarsat V. Proteinase 3: the odd one out that became an_x000D_ autoantigen. J Leukoc Biol. 2017 Sep;102(3):689-698._x000D_ _x000D_ 4: Sharma RK, L√∂vstr√∂m B, Gunnarsson I, Malmstr√∂m V. Proteinase 3 Autoreactivity_x000D_ in Anti-Neutrophil Cytoplasmic Antibody-associated vasculitis-Immunological_x000D_ versus clinical features. Scand J Immunol. 2020 Nov;92(5):e12958._x000D_ _x000D_ 5: Crisford H, Sapey E, Stockley RA. Proteinase 3; a potential target in chronic_x000D_ obstructive pulmonary disease and other chronic inflammatory diseases. Respir_x000D_ Res. 2018 Sep 20;19(1):180._x000D_ _x000D_ 6: Cohen Tervaert JW. Should proteinase_3 and myeloperoxidase anti-neutrophil_x000D_ cytoplasmic antibody vasculitis be treated differently: part 2. Nephrol Dial_x000D_ Transplant. 2019 Mar 1;34(3):384-387._x000D_ _x000D_ 7: Watts RA. Should proteinase_3 and myeloperoxidase anti-neutrophil cytoplasmic_x000D_ antibody vasculitis be treated differently: part 1. Nephrol Dial Transplant._x000D_ 2019 Mar 1;34(3):381-383._x000D_ _x000D_ 8: Witko-Sarsat V, Thieblemont N. Granulomatosis with polyangiitis (Wegener_x000D_ granulomatosis): A proteinase_3 driven disease? Joint Bone Spine. 2018_x000D_ Mar;85(2):185-189._x000D_ _x000D_ 9: Yanai K, Kaku Y, Hirai K, Kaneko S, Minato S, Mutsuyoshi Y, Ishii H, Kitano_x000D_ T, Shindo M, Miyazawa H, Ito K, Ueda Y, Hiruta M, Ookawara S, Ueda Y, Morishita_x000D_ Y. Proteinase 3-antineutrophil cytoplasmic antibody-positive necrotizing_x000D_ crescentic glomerulonephritis complicated by infectious endocarditis: a case_x000D_ report. J Med Case Rep. 2019 Dec 5;13(1):356._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/31995266/">10: N'Guessan K, Grzywa R, Seren S, Gabant G, Juliano MA, Moniatte M, van_x000D_ Dorsselaer A, Bieth JG, Kellenberger C, Gauthier F, Wysocka M, Lesner A,_x000D_ Sienczyk M, Cadene M, Korkmaz B. Human proteinase 3 resistance to inhibition_x000D_ extends to alpha-2 macroglobulin. FEBS J. 2020 Sep;287(18):4068-4081. </a>_x000D_ _x000D_ <strong>Products Related to Proteinase 3 (PR3, Highly Pure)</strong><a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>