Cyclic somatostatin

Cyclic somatostatin (SRIF-14) is a growth hormone-release inhibiting factor used in the research of severe, acute hemorrhages of gastroduodenal ulcers. Cyclic somatostatin is a neuropeptide co-stored with acetylcholine in the cardiac parasympathetic innervation, exerts influences directly on contraction of ventricular cardiomyocytes. Cyclic somatostatin inhibits the contractile response of isoprenaline with an IC50 value of 13 nM. Cyclic somatostatin can be used for the research of cardiovascular disease[1][2][3].

Product Specifications

CAS Number

[38916-34-6]

Product Name Alternative

SRIF-14; Somatostatin-14

UNSPSC

12352209

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Peptides

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Cyclic-somatostatin.html

Purity

99.87

Solubility

DMF : 100 mg/mL (ultrasonic) |DMSO : ≥ 50 mg/mL|H2O : 100 mg/mL (ultrasonic)

Smiles

O=C([C@@H](N)C)NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CO)=O)[C@@H](C)O)=O)CC2=CC=CC=C2)=O)[C@@H](C)O)=O)CCCCN)=O)CC3=CNC4=CC=CC=C34)=O)CC5=CC=CC=C5)=O)CC6=CC=CC=C6)=O)CC(N)=O)=O)CCCCN)=O)CSSC[C@H](NC1=O)C(O)=O)=O

Molecular Formula

C76H104N18O19S2

Molecular Weight

1637.88

Precautions

H302, H315, H319, H335

References & Citations

[1]Murray F, et al. Positive and negative contractile effects of somatostatin-14 on rat ventricular cardiomyocytes. J Cardiovasc Pharmacol. 2001 Mar;37 (3) :324-32.|[2]Bell D, et al. SRIF receptor subtype expression and involvement in positive and negative contractile effects of somatostatin-14 (SRIF-14) in ventricular cardiomyocytes. Cell Physiol Biochem. 2008;22 (5-6) :653-64.|[3]https://pubmed.ncbi.nlm.nih.gov/9374319/