Adoprazine (hydrochloride)
Adoprazine (SLV313) hydrochloride is a full 5-HT1A receptor agonist with a pEC50 of 9 at cloned h5-HT1A receptors. Adoprazine hydrochloride is a full D2 and D3 receptor antagonist with pA2s of 9.3 and 8.9 at hD2 and hD3 receptors, respectively. Adoprazine has the characteristics of atypical antipsychotics[1].
Product Specifications
CAS Number
222551-05-5
Product Name Alternative
SLV313 (hydrochloride)
UNSPSC
12352005
Target
5-HT Receptor; Dopamine Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Assay Protocol
https://www.medchemexpress.com/adoprazine-hydrochloride.html
Smiles
FC1=CC=C(C2=CN=CC(CN3CCN(C4=C5OCCOC5=CC=C4)CC3)=C2)C=C1.[H]Cl
Molecular Formula
C24H25ClFN3O2
Molecular Weight
441.93
References & Citations
[1]Andrew C McCreary, et al. SLV313 (1- (2,3-dihydro-benzo[1,4]dioxin-5-yl) -4- [5- (4-fluoro-phenyl) -pyridin-3-ylmethyl]-piperazine monohydrochloride) : a novel dopamine D2 receptor antagonist and 5-HT1A receptor agonist potential antipsychotic drug. Neuropsych|[2]Liesbeth A Bruins Slot, et al. Differential profile of antipsychotics at serotonin 5-HT1A and dopamine D2S receptors coupled to extracellular signal-regulated kinase. Eur J Pharmacol. 2006 Mar 18;534 (1-3) :63-70.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
5-HT1 Receptor
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