(R) - (-) -Gossypol acetic acid

(R) - (-) -Gossypol acetic acid (AT-101 (acetic acid) ) is the levorotatory isomer of a natural product Gossypol. AT-101 is determined to bind to Bcl-2, Mcl-1 and Bcl-xL proteins with Kis of 260±30 nM, 170±10 nM, and 480±40 nM, respectively.

Product Specifications

CAS Number

[866541-93-7]

Product Name Alternative

AT-101 (acetic acid) ; (-) -Gossypol acetic acid; (R) -Gossypol acetic acid

UNSPSC

12352005

Target

Autophagy; Bcl-2 Family

Type

Reference compound

Related Pathways

Apoptosis; Autophagy

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/AT-101-acetic-acid.html

Purity

98.93

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC1=C2C(C=O)=C(O)C(O)=C(C(C)C)C2=CC(C)=[C@]1[C@]3=C(C)C=C4C(C(C)C)=C(O)C(O)=C(C=O)C4=C3O.CC(O)=O

Molecular Formula

C32H34O10

Molecular Weight

578.61

References & Citations

[1]Oliver CL, et al. In vitro effects of the BH3 mimetic, (-) -Gossypol, on head and neck squamous cell carcinoma cells. Clin Cancer Res. 2004 Nov 15;10 (22) :7757-63.|[2]Sun Y, et al. Apogossypolone, a nonpeptidic small molecule inhibitor targeting Bcl-2 family proteins, effectively inhibits growth of diffuse large cell lymphoma cells in vitro and in vivo. Cancer Biol Ther. 2008 Sep;7 (9) :1418-26.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, protect from light, stored under nitrogen)

Scientific Category

Reference compound1

Clinical Information

Phase 3

Isoform

Bcl-2; Bcl-xL; Mcl-1

Citation 01

Nat Commun. 2023 Jun 10;14 (1) :3445.|Cancer Lett. 2019 Oct 1:461:31-43.|Microb Pathog. 2024 Sep 21:106960.|Toxics. 2025 Sep 9;13 (9) :763.|Transbound Emerg Dis. 2023 Nov 11:2023:9073566.