P-gp modulator-5
P-gp modulator-5 (compound 25) is a modulator of P-gp and can inhibit the proliferation of multidrug resistant (MDR) tumors. P-gp modulator-5 inhibits the activity of drug efflux pumps in MDR cells, leading to a large accumulation of ROS and altered cell cycle profiles[1].
Product Specifications
UNSPSC
12352211
Target
P-glycoprotein
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/p-gp-modulator-5.html
Smiles
O=C1C=C(C(C2=C(C(C)=[N+](C=C21)[O-])C(OC)=O)=O)NCC3=CC=CC=C3
Molecular Formula
C19H16N2O5
Molecular Weight
352.34
References & Citations
[1]Discovery of Potent Isoquinolinequinone N-Oxides to Overcome Cancer Multidrug Resistance
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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