Phospho-Shp1 (Tyr536) Rabbit APC Conjugate

<strong>Phospho-Shp1 (Tyr536) Rabbit APC Conjugate </strong>_x000D_ <strong>Catalog number:</strong> B2018671_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 10 ug_x000D_ <strong>Molecular Weight or Concentration:</strong> N/A_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> 2-8°C_x000D_ <strong>Keywords:</strong> Tyrosine-protein phosphatase non-receptor type 6, Hematopoietic cell protein-tyrosine phosphatase, Protein-tyrosine phosphatase 1C, PTP-1C, SH-PTP1, PTPN6, HCP, PTP1C_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Chen KF, Tai WT, Hsu CY, Huang JW, Liu CY, Chen PJ, Kim I, Shiau CW. Blockade of STAT3 activation by sorafenib derivatives through enhancing SHP-1 phosphatase activity Eur J Med Chem. 2012 Sep;55:220-7._x000D_ 2: Tibaldi E, Pagano MA, Frezzato F, Trimarco V, Facco M, Zagotto G, Ribaudo G, Pavan V, Bordin L, Visentin A, Zonta F, Semenzato G, Brunati AM, Trentin L. Targeted activation of the SHP-1/PP2A signaling axis elicits apoptosis of chronic lymphocytic leukemia cells Haematologica. 2017 Aug;102(8):1401-1412._x000D_ 3: Albini E, Rosini V, Gargaro M, Mondanelli G, Belladonna ML, Pallotta MT, Volpi C, Fallarino F, Macchiarulo A, Antognelli C, Bianchi R, Vacca C, Puccetti P, Grohmann U, Orabona C. Distinct roles of immunoreceptor tyrosine-based motifs in immunosuppressive indoleamine 2,3-dioxygenase 1 J Cell Mol Med. 2017 Jan;21(1):165-176._x000D_ 4: Bian Y, Yuan L, Yang X, Weng L, Zhang Y, Bai H, Chen J. SMURF1-mediated ubiquitylation of SHP-1 promotes cell proliferation and invasion of endometrial stromal cells in endometriosis Ann Transl Med. 2021 Mar;9(5):362._x000D_ 5: Karampetsou MP, Andonopoulos AP, Liossis SN. Treatment with TNFα blockers induces phenotypical and functional aberrations in peripheral B cells Clin Immunol. 2011 Jul;140(1):8-17._x000D_ 6: Crute BW, Sheraden R, Ott VL, Harley ITW, Getahun A, Cambier JC. Inhibitory Receptor Trap: A Platform for Discovery of Inhibitory Receptors That Utilize Inositol Lipid and Phosphotyrosine Phosphatase Effectors Front Immunol. 2020 Oct 21;11:592329._x000D_ 7: Edwards LJ, Evavold BD. Destabilization of peptide:MHC interaction induces IL-2 resistant anergy in diabetogenic T cells J Autoimmun. 2013 Aug;44:82-90._x000D_ 8: Petti F, Thelemann A, Kahler J, McCormack S, Castaldo L, Hunt T, Nuwaysir L, Zeiske L, Haack H, Sullivan L, Garton A, Haley JD. Temporal quantitation of mutant Kit tyrosine kinase signaling attenuated by a novel thiophene kinase inhibitor OSI-930 Mol Cancer Ther. 2005 Aug;4(8):1186-97._x000D_ 9: Sugano M, Tsuchida K, Hata T, Makino N. RNA interference targeting SHP-1 attenuates myocardial infarction in rats FASEB J. 2005 Dec;19(14):2054-6._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/22180308">10: Tai WT, Cheng AL, Shiau CW, Liu CY, Ko CH, Lin MW, Chen PJ, Chen KF. Dovitinib induces apoptosis and overcomes sorafenib resistance in hepatocellular carcinoma through SHP-1-mediated inhibition of STAT3 Mol Cancer Ther. 2012 Feb;11(2):452-63. </a>_x000D_ _x000D_ <strong>Products Related to Phospho-Shp1 (Tyr536) Rabbit APC Conjugate can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>