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DNA Gyrase-IN-11

DNA Gyrase-IN-11 (Compound 23Be) is an inhibitor for protein synthesis (IC50 is 0.74 μM) and DNA replication. DNA Gyrase-IN-11 inhibits DNA gyrase, that inhibits E. coli DNA supercoiling with IC50 of 11.9 μM. DNA Gyrase-IN-11 exhibits antibacterial efficacy, that inhibits Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Staphylococcus aureus, with MICs of 0.008-0.25 μg/mL[1].

Product Specifications

CAS Number

[2497486-58-3]

UNSPSC

12352005

Target

Bacterial; DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/dna-gyrase-in-11.html

Smiles

O=C(NC)C1=CC(C#CCO/N=C([C@H](C)C[C@](OC)(C)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](OC(CCNCCCCNC3=CC4=C(C(C(C(O)=O)=CN4C5CC5)=O)C=C3F)=O)[C@@H](C)C6=O)/[C@@H]([C@@H]7[C@@](OC(O7)=O)(C)[C@@H](CC)O6)C)=CN=C1

Molecular Formula

C61H84FN7O16

Molecular Weight

1190.36

References & Citations

[1]Ma CX, et al., Design, synthesis and structure-activity relationships of novel non-ketolides: 9-Oxime clarithromycin featured with seven-to thirteen-atom-length diamine linkers at 3-OH. Eur J Med Chem. 2024 Jun 25;276:116630.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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