DNA Gyrase-IN-11
DNA Gyrase-IN-11 (Compound 23Be) is an inhibitor for protein synthesis (IC50 is 0.74 μM) and DNA replication. DNA Gyrase-IN-11 inhibits DNA gyrase, that inhibits E. coli DNA supercoiling with IC50 of 11.9 μM. DNA Gyrase-IN-11 exhibits antibacterial efficacy, that inhibits Streptococcus pneumoniae, Streptococcus pyogenes, Haemophilus influenzae and Staphylococcus aureus, with MICs of 0.008-0.25 μg/mL[1].
Product Specifications
CAS Number
2497486-58-3
UNSPSC
12352005
Target
Bacterial; DNA/RNA Synthesis
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/dna-gyrase-in-11.html
Smiles
O=C(NC)C1=CC(C#CCO/N=C([C@H](C)C[C@](OC)(C)[C@H](O[C@@H]2O[C@H](C)C[C@H](N(C)C)[C@H]2O)[C@@H](C)[C@H](OC(CCNCCCCNC3=CC4=C(C(C(C(O)=O)=CN4C5CC5)=O)C=C3F)=O)[C@@H](C)C6=O)/[C@@H]([C@@H]7[C@@](OC(O7)=O)(C)[C@@H](CC)O6)C)=CN=C1
Molecular Formula
C61H84FN7O16
Molecular Weight
1190.36
References & Citations
[1]Ma CX, et al., Design, synthesis and structure-activity relationships of novel non-ketolides: 9-Oxime clarithromycin featured with seven-to thirteen-atom-length diamine linkers at 3-OH. Eur J Med Chem. 2024 Jun 25;276:116630.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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