SHBG(141–161)

SHBG 141-161 is a GPRC6A receptor agonist. SHBG 141-161 mimics the action of GPRC6A endogenous agonist uncarboxylated osteocalcin by binding to GPRC6A and promoting downstream signaling to increase testosterone and insulin secretion. SHBG 141-161 also reduces the affinity of GPRC6A to GDP protein by binding to the outer cell domain of GPRC6A thus affecting the dynamics of signal transduction. SHBG 141-161 can be used to study GPRC6A in energy metabolism and endocrine regulation[1].

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[1]De Toni L, et al. SHBG141–161 domain-peptide stimulates GPRC6A-mediated response in leydig and β-Langerhans cell lines[J]. Scientific Reports, 2019, 9(1): 19432.