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MD01-67

MD01-67 is a selective macrocyclic compound targeting the neurotensin receptor type 2 (NTS2), with Ki of 2.9 nM. MD01-67 exhibits analgesic and tactile hypersensitivity reducing activity in rats acute/persistent/chronic inflammatory pain models[1].

Product Specifications

CAS Number

[2468971-42-6]

UNSPSC

12352209

Target

Neurotensin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/md01-67.html

Smiles

OC(C=C1)=CC=C1C[C@H](NC([C@H]2NC([C@@H](NC([C@@H](NC([C@H](C/C=C/C2)N)=O)CCCCN)=O)CCCCN)=O)=O)C(N[C@H](C(O)=O)CC3CCCC3)=O

Molecular Formula

C37H58N8O8

Molecular Weight

742.91

References & Citations

[1]Desgagné M, et al., Development of Macrocyclic Neurotensin Receptor Type 2 (NTS2) Opioid-Free Analgesics. Angew Chem Int Ed Engl. 2024 Nov 18;63 (47) :e202405941.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-P10767/MD01-67-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-P10767/

Scientific Category

Peptides

Clinical Information

No Development Reported

Curated Selection

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