Corilagin

Corilagin, a gallotannin, has anti-tumor, anti-inflammatory and hepatoprotective activities. Corilagin inhibits activity of reverse transcriptase of RNA tumor viruses. Corilagin also inhibits the growth of Staphylococcus aureus with a MIC of 25 μg/mL. Corilagin shows anti-tumor activity on hepatocellular carcinoma and ovarian cancer model. Corilagin shows low toxicity to normal cells and tissues[1][2][3].

Product Specifications

CAS Number

[23094-69-1]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; Autophagy; Bacterial; Reverse Transcriptase; Toll-like Receptor (TLR)

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Autophagy; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/corilagin.html

Purity

99.96

Solubility

DMSO : 100 mg/mL (ultrasonic)|H2O : 5 mg/mL (ultrasonic;warming;heat to 60°C)

Smiles

OC1=C(C2=C(C(OC[C@H]3O[C@@H](OC(C4=CC(O)=C(O)C(O)=C4)=O)[C@@H](O)[C@@H]([C@H]3O)OC5=O)=O)C=C(O)C(O)=C2O)C5=CC(O)=C1O

Molecular Formula

C27H22O18

Molecular Weight

634.45

Precautions

H302, H315, H319, H335

References & Citations

[1]Li X, et al. Corilagin, a promising medicinal herbal agent. Biomed Pharmacother. 2018 Mar;99:43-50.|[2]Xu J, et al. Corilagin induces apoptosis, autophagy and ROS generation in gastric cancer cells in vitro. Int J Mol Med. 2019 Feb;43 (2) :967-979. |[3]Jia L, et al. A potential anti-tumor herbal medicine, Corilagin, inhibits ovarian cancer cell growth through blocking the TGF-β signaling pathways. BMC Complement Altern Med. 2013 Feb 15;13:33. |[4]Hau DK, et al. In vivo anti-tumour activity of corilagin on Hep3B hepatocellular carcinoma. Phytomedicine. 2010 Dec 15;18 (1) :11-5. |[5]Liu FC, et al. Corilagin reduces acetaminophen-induced hepatotoxicity through MAPK and NF-κB signaling pathway in a mouse model. Am J Transl Res. 2020 Sep 15;12 (9) :5597-5607. |[6]Wang Z, et al. Corilagin attenuates aerosol bleomycin-induced experimental lung injury. Int J Mol Sci. 2014 May 30;15 (6) :9762-79.