(S, S) -Z-FA-FMK
(S, S) -Z-FA-FMK is a cell-permeable, irreversible cathepsin B inhibitor. (S, S) -Z-FA-FMK blocks LPS-induced production of IL-1α and IL-1β. (S, S) -Z-FA-FMK can be used as a negative control for caspase-1 and caspase-2 inhibitors because it lacks an aspartic acid residue at the P1 position[1][2].
Product Specifications
CAS Number
105637-38-5
UNSPSC
12352209
Target
Cathepsin
Type
Peptides
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/s-s-z-fa-fmk.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=CC=CC=C1)N[C@@H](CC2=CC=CC=C2)C(N[C@@H](C)C(CF)=O)=O
Molecular Formula
C21H23FN2O4
Molecular Weight
386.42
References & Citations
[1]Koike S, et al. Advanced Glycation End-Products Induce Apoptosis of Vascular Smooth Muscle Cells: A Mechanism for Vascular Calcification. Int J Mol Sci. 2016;17 (9) :1567. Published 2016 Sep 16.|[2]Harrison JS, et al. The role of VDR and BIM in potentiation of cytarabine-induced cell death in human AML blasts. Oncotarget. 2016;7 (24) :36447-36460.
Shipping Conditions
Room temperature
Scientific Category
Peptides
Clinical Information
No Development Reported
Frequently Asked Questions
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