Dimethyl malonate

Dimethyl malonate is a competitive inhibitor of succinate dehydrogenase (SDH) . Dimethyl malonate is able to cross the blood-brain barrier and hydrolyse to malonate. Dimethyl malonate reduces neuronal apoptosis[1].

Product Specifications

CAS Number

[108-59-8]

UNSPSC

12352211

Hazard Statement

H227, H319

Target

Apoptosis

Type

Natural Products

Related Pathways

Apoptosis

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/dimethyl-malonate.html

Concentration

10mM

Purity

99.93

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

O=C(OC)CC(OC)=O

Molecular Formula

C5H8O4

Molecular Weight

132.11

Precautions

H227, H319

References & Citations

[1]Xu J, et al. Inhibiting Succinate Dehydrogenase by Dimethyl Malonate Alleviates Brain Damage in a Rat Model of Cardiac Arrest. Neuroscience. 2018 Nov 21;393:24-32.