E3 Ligase Ligand-linker Conjugate 50

E3 Ligase Ligand-linker Conjugate 50 is a conjugate of E3 ligase ligand and linker, consisting of (S, R, S) -AHPC (HY-125845) and the corresponding Linker. (S, R, S) -AHPC is a VH032-based von Hippel-Lindau (VHL) ligand that recruits VHL proteins. E3 Ligase Ligand-linker Conjugate 50 can be used as a key intermediate for the synthesis of complete PROTAC molecules.

Product Specifications

CAS Number

[2918813-56-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/e3-ligase-ligand-linker-conjugate-50.html

Solubility

10 mM in DMSO

Smiles

O=C([C@H]1N(C[C@@H](C1)O)C([C@H](C(C)(C)C)NC(C2CCN(CC2)C(OC(C)(C)C)=O)=O)=O)NCC(C=C3)=CC=C3C(SC=N4)=C4C

Molecular Formula

C33H47N5O6S

Molecular Weight

641.82

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Burslem GM, et al. Targeting BCR-ABL1 in Chronic Myeloid Leukemia by PROTAC-mediated Targeted Protein Degradation. Cancer Res. 2019 Jul 16. pii: canres.1236.2019.