Recombinant Human CDK2 & Cyclin E2 Protein (Full Length, GST Tag, Active)

<strong>Recombinant Human CDK2 &amp; Cyclin E2 Protein (Full Length, GST Tag, Active)</strong>_x000D_ <strong>Catalog number:</strong> B2018991_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 5 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> CDK2 ~58 kDa; CyclinE2 ~72 kDa_x000D_ <strong>Supplied as:</strong> Powder_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> −80°C_x000D_ <strong>Keywords:</strong> Recombinant Human CDK2 &amp; Cyclin E2 Protein (Full Length, GST Tag), Active_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Johansson C, Graham SV, Dornan ES, Morgan IM. The human papillomavirus 16 E2 protein is stabilised in S phase Virology. 2009 Nov 25;394(2):194-9._x000D_ 2: Lin BY, Ma T, Liu JS, Kuo SR, Jin G, Broker TR, Harper JW, Chow LT. HeLa cells are phenotypically limiting in cyclin E/CDK2 for efficient human papillomavirus DNA replication J Biol Chem. 2000 Mar 3;275(9):6167-74._x000D_ 3: Kitagawa M, Higashi H, Suzuki-Takahashi I, Segawa K, Hanks SK, Taya Y, Nishimura S, Okuyama A. Phosphorylation of E2F-1 by cyclin A-cdk2 Oncogene. 1995 Jan 19;10(2):229-36._x000D_ 4: Masamha CP, Benbrook DM. Cyclin D1 degradation is sufficient to induce G1 cell cycle arrest despite constitutive expression of cyclin E2 in ovarian cancer cells Cancer Res. 2009 Aug 15;69(16):6565-72._x000D_ 5: Boratyn E, Nowak I, Karnas E, Ryszawy D, Wnuk D, Polus A, Durbas M, Horwacik I, Rokita H. MCPIP1 overexpression in human neuroblastoma cell lines causes cell-cycle arrest by G1/S checkpoint block J Cell Biochem. 2020 Jun;121(5-6):3406-3425._x000D_ 6: Sun FQ, Duan H, Wang S, Li JJ. 17β-Estradiol Induces Overproliferation in Adenomyotic Human Uterine Smooth Muscle Cells of the Junctional Zone Through Hyperactivation of the Estrogen Receptor-Enhanced RhoA/ROCK Signaling Pathway Reprod Sci. 2015 Nov;22(11):1436-44._x000D_ 7: Mukhopadhyay P, Ali MA, Nandi A, Carreon P, Choy H, Saha D. The cyclin-dependent kinase 2 inhibitor down-regulates interleukin-1beta-mediated induction of cyclooxygenase-2 expression in human lung carcinoma cells Cancer Res. 2006 Feb 1;66(3):1758-66._x000D_ 8: Prall OW, Carroll JS, Sutherland RL. A low abundance pool of nascent p21WAF1/Cip1 is targeted by estrogen to activate cyclin E*Cdk2 J Biol Chem. 2001 Nov 30;276(48):45433-42._x000D_ 9: Ma HT, Tsang YH, Marxer M, Poon RY. Cyclin A2-cyclin-dependent kinase 2 cooperates with the PLK1-SCFbeta-TrCP1-EMI1-anaphase-promoting complex/cyclosome axis to promote genome reduplication in the absence of mitosis Mol Cell Biol. 2009 Dec;29(24):6500-14._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/27425595">10: Milewski D, Pradhan A, Wang X, Cai Y, Le T, Turpin B, Kalinichenko VV, Kalin TV. FoxF1 and FoxF2 transcription factors synergistically promote rhabdomyosarcoma carcinogenesis by repressing transcription of p21(Cip1) CDK inhibitor Oncogene. 2017 Feb 9;36(6):850-862. </a>_x000D_ _x000D_ <strong>Products Related to Recombinant Human CDK2 &amp; Cyclin E2 Protein (Full Length, GST Tag, Active) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>