Alagebrium chloride

Alagebrium chloride (ALT711) is an advanced glycation end product (AGE) inhibitor.

Product Specifications

CAS Number

[341028-37-3]

Product Name Alternative

ALT711

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/Alagebrium_chloride.html

Concentration

10mM

Purity

99.82

Solubility

DMSO : ≥ 25 mg/mL|H2O : 50 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CC=C1)C[N+]2=CSC(C)=C2C.[Cl-]

Molecular Formula

C13H14ClNOS

Molecular Weight

267.78

Precautions

H302, H315, H319, H335

References & Citations

[1]Watson AM, et al. Alagebrium reduces glomerular fibrogenesis and inflammation beyond preventing RAGEactivation in diabetic apolipoprotein E knockout mice. Diabetes. 2012 Aug;61 (8) :2105-13.|[2]Wang H, et al. Alagebrium inhibits neointimal hyperplasia and restores distributions of wall shear stress by reducing downstream vascular resistance in obese and diabetic rats. Am J Physiol Heart Circ Physiol. 2015 Oct;309 (7) :H1130-40.